Evaluation of inhibitory guanine nucleotide regulatory protein Gi function in hepatocyte and liver membranes from obese Zucker (fa/fa) rats and their lean (Fa/?) littermates
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منابع مشابه
Cytokine-induced fever in obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats.
In earlier work, we reported that genetically obese ( fa/ fa) Zucker rats exhibited significantly greater anorexia than did lean ( Fa/ Fa) Zucker rats to intracerebroventricular infusion of interleukin (IL)-1β. Here, we investigated the fever response of obese ( fa/ fa) and lean ( Fa/ Fa) Zucker rats to intracerebroventricular microinfusion of IL-1β as well as to the following other cytokines: ...
متن کاملEffects of simmondsin on food intake, growth, and metabolic variables in lean (+/?) and obese (fa/fa) Zucker rats.
Incorporation of 2.5 g/kg of the anorexigen, simmondsin, in the diet resulted in food intake reduction in both lean and obese Zucker rats; however, the obese rats were much more sensitive to the food intake-reducing activity of simmondsin. In both obese and lean simmondsin-treated Zucker rats, growth was slower than in control rats, but was the same as that in pair-fed animals. The 24 h heat pr...
متن کاملLean ( Fa/ Fa) but not obese ( fa/ fa) Zucker rats release cholecystokinin at PVN after a gavaged meal.
Neuropeptides play an important role in the integration of dietary signals. Cholecystokinin (CCK) has been implicated in regulating ingestive behavior, particularly satiety. The primary objective of this study was to examine whether the hyperphagia characteristic of obese ( fa/ fa) rats involves impaired neural CCK secretion. Dynamic release of CCK at the hypothalamic paraventricular nucleus (P...
متن کاملBone responses to body weight and moderate treadmill exercising in growing male obese (fa/fa) and lean Zucker rats.
OBJECTIVE To evaluate if exercise in a young growing model of obesity would be able to reduce adiposity without adversely affecting bone. METHODS Obese (fa/fa) and lean (Fa/Fa) male Zucker rats were randomly assigned (n=8-9 rats/group) to no exercise or to a moderate treadmill exercise regimen consisting of a speed of 20 m/min for approximately 1 h, 5 d/wk for 9 wks. Bone morphometry, total b...
متن کاملSoy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats.
Hepatic steatosis is commonly present during the development of insulin resistance, and it is a clear sign of lipotoxicity attributable in part to an accelerated lipogenesis. There is evidence that a soy protein diet prevents the overexpression of hepatic sterol-regulatory element binding protein-1 (SREBP-1), decreasing lipid accumulation. Therefore, the aim of the present work was to study whe...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1991
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00400274